Glucosamine HCL

Glucosamine is a natural compound found in cartilage — the tough tissue that cushions joints.

In supplement form, glucosamine is harvested from shells of shellfish or made in a lab. There are several forms of glucosamine, including glucosamine sulfate, glucosamine hydrochloride and N-acetyl glucosamine. These supplements aren't considered interchangeable.
People use glucosamine sulfate orally to treat a painful condition caused by the inflammation, breakdown and eventual loss of cartilage (osteoarthritis).

Research on glucosamine use for specific conditions shows:

Osteoarthritis. Oral use of glucosamine sulfate might provide some pain relief for people with osteoarthritis of the knee.

Some research shows that it may also help slow knee joint degeneration associated with osteoarthritis. More studies are needed to determine the benefits of glucosamine sulfate supplements for osteoarthritis of the hip, spine or hand.
Rheumatoid arthritis. Early research suggests that oral use of glucosamine hydrochloride might reduce pain related to rheumatoid arthritis. However, researchers didn't see an improvement in inflammation or the number of painful or swollen joints.

When considering glucosamine, read product labels carefully to make sure you choose the correct form. There's less clinical evidence to support the use of N-acetyl glucosamine in treating osteoarthritis, and more research is needed to confirm its benefits.

Glucosamine sulfate might provide some pain relief for people with osteoarthritis. The supplement appears to be safe and might be a helpful option for people who can't take nonsteroidal anti-inflammatory drugs (NSAIDs). While study results are mixed, glucosamine sulfate might be worth a try.